There are
349 mi
from Sioux Falls, SD to Leavenworth, KS
That's the driving distance. It would take 6 hours 19 mins to go from Sioux Falls, South Dakota to Leavenworth, Kansas.
The flight distance (direct flight from Sioux Falls, SD to Leavenworth, KS) is 307 mi.
349 mi = 562.32 kms