There are
1,623 mi
from Sioux Falls, SD to Lake Mary, FL
That's the driving distance. It would take 1 day 5 hours to go from Sioux Falls, South Dakota to Lake Mary, Florida.
The flight distance (direct flight from Sioux Falls, SD to Lake Mary, FL) is 1,329.89 mi.
1,623 mi = 1.61 kms