Miles between Sioux Falls, SD and Kirksville, MO

There are
438 mi
from Sioux Falls, SD to Kirksville, MO

That's the driving distance. It would take 8 hours 6 mins to go from Sioux Falls, South Dakota to Kirksville, Missouri.

The flight distance (direct flight from Sioux Falls, SD to Kirksville, MO) is 313.94 mi.

438 mi = 704.10 kms