There are
504 mi
from Sioux Falls, SD to Kewanee, IL
That's the driving distance. It would take 9 hours 8 mins to go from Sioux Falls, South Dakota to Kewanee, Illinois.
The flight distance (direct flight from Sioux Falls, SD to Kewanee, IL) is 380.46 mi.
504 mi = 810.80 kms