There are
468 mi
from Sioux Falls, SD to Keokuk, IA
That's the driving distance. It would take 8 hours 41 mins to go from Sioux Falls, South Dakota to Keokuk, Iowa.
The flight distance (direct flight from Sioux Falls, SD to Keokuk, IA) is 348.55 mi.
468 mi = 753.17 kms