There are
885 mi
from Sioux Falls, SD to Jeffersontown, KY
That's the driving distance. It would take 16 hours 1 min to go from Sioux Falls, South Dakota to Jeffersontown, Kentucky.
The flight distance (direct flight from Sioux Falls, SD to Jeffersontown, KY) is 688.61 mi.
885 mi = 1,423.98 kms