There are
333 mi
from Sioux Falls, SD to Jamestown, ND
That's the driving distance. It would take 5 hours 22 mins to go from Sioux Falls, South Dakota to Jamestown, North Dakota.
The flight distance (direct flight from Sioux Falls, SD to Jamestown, ND) is 251.89 mi.
333 mi = 536.12 kms