There are
1,486 mi
from Sioux Falls, SD to Jacksonville, NC
That's the driving distance. It would take 1 day 4 hours to go from Sioux Falls, South Dakota to Jacksonville, North Carolina.
The flight distance (direct flight from Sioux Falls, SD to Jacksonville, NC) is 1,193.77 mi.
1,486 mi = 2,391.48 kms