There are
1,532 mi
from Sioux Falls, SD to Jacksonville Beach, FL
That's the driving distance. It would take 1 day 4 hours to go from Sioux Falls, South Dakota to Jacksonville Beach, Florida.
The flight distance (direct flight from Sioux Falls, SD to Jacksonville Beach, FL) is 1,242.85 mi.
1,532 mi = 1.61 kms