There are
1,245 mi
from Sioux Falls, SD to Ithaca, NY
That's the driving distance. It would take 23 hours 15 mins to go from Sioux Falls, South Dakota to Ithaca, New York.
The flight distance (direct flight from Sioux Falls, SD to Ithaca, NY) is 1,021.04 mi.
1,245 mi = 1.61 kms