There are
1,269 mi
from Sioux Falls, SD to Hyattsville, MD
That's the driving distance. It would take 23 hours 33 mins to go from Sioux Falls, South Dakota to Hyattsville, Maryland.
The flight distance (direct flight from Sioux Falls, SD to Hyattsville, MD) is 1,071.14 mi.
1,269 mi = 1.61 kms