There are
858 mi
from Sioux Falls, SD to Hopkinsville, KY
That's the driving distance. It would take 15 hours 44 mins to go from Sioux Falls, South Dakota to Hopkinsville, Kentucky.
The flight distance (direct flight from Sioux Falls, SD to Hopkinsville, KY) is 669.71 mi.
858 mi = 1,380.97 kms