There are
1,595 mi
from Sioux Falls, SD to Hesperia, CA
That's the driving distance. It would take 1 day 3 hours to go from Sioux Falls, South Dakota to Hesperia, California.
The flight distance (direct flight from Sioux Falls, SD to Hesperia, CA) is 1,268.25 mi.
1,595 mi = 1.61 kms