There are
1,304 mi
from Sioux Falls, SD to Greenwood, SC
That's the driving distance. It would take 1 day to go from Sioux Falls, South Dakota to Greenwood, South Carolina.
The flight distance (direct flight from Sioux Falls, SD to Greenwood, SC) is 1,011.96 mi.
1,304 mi = 2,099.19 kms