There are
1,497 mi
from Sioux Falls, SD to Gainesville, FL
That's the driving distance. It would take 1 day 3 hours to go from Sioux Falls, South Dakota to Gainesville, Florida.
The flight distance (direct flight from Sioux Falls, SD to Gainesville, FL) is 1,244.38 mi.
1,497 mi = 1.61 kms