There are
1,524 mi
from Sioux Falls, SD to Fernandina Beach, FL
That's the driving distance. It would take 1 day 4 hours to go from Sioux Falls, South Dakota to Fernandina Beach, Florida.
The flight distance (direct flight from Sioux Falls, SD to Fernandina Beach, FL) is 1,219.56 mi.
1,524 mi = 1.61 kms