There are
671 mi
from Sioux Falls, SD to Farmington, MO
That's the driving distance. It would take 12 hours 21 mins to go from Sioux Falls, South Dakota to Farmington, Missouri.
The flight distance (direct flight from Sioux Falls, SD to Farmington, MO) is 516.55 mi.
671 mi = 1,079.59 kms