There are
1,389 mi
from Sioux Falls, SD to Clayton, NC
That's the driving distance. It would take 1 day 2 hours to go from Sioux Falls, South Dakota to Clayton, North Carolina.
The flight distance (direct flight from Sioux Falls, SD to Clayton, NC) is 1,110.58 mi.
1,389 mi = 2,234.87 kms