Miles between Sioux Falls, SD and Clayton, MO

There are
609 mi
from Sioux Falls, SD to Clayton, MO

That's the driving distance. It would take 11 hours 9 mins to go from Sioux Falls, South Dakota to Clayton, Missouri.

The flight distance (direct flight from Sioux Falls, SD to Clayton, MO) is 474.28 mi.

609 mi = 979.46 kms