There are
870 mi
from Sioux Falls, SD to Clarksville, IN
That's the driving distance. It would take 15 hours 38 mins to go from Sioux Falls, South Dakota to Clarksville, Indiana.
The flight distance (direct flight from Sioux Falls, SD to Clarksville, IN) is 675.86 mi.
870 mi = 1,399.84 kms