There are
944 mi
from Sioux Falls, SD to Chillicothe, OH
That's the driving distance. It would take 17 hours 23 mins to go from Sioux Falls, South Dakota to Chillicothe, Ohio.
The flight distance (direct flight from Sioux Falls, SD to Chillicothe, OH) is 766.74 mi.
944 mi = 1,519.96 kms