There are
594 mi
from Sioux Falls, SD to Chesterfield, MO
That's the driving distance. It would take 10 hours 50 mins to go from Sioux Falls, South Dakota to Chesterfield, Missouri.
The flight distance (direct flight from Sioux Falls, SD to Chesterfield, MO) is 464.10 mi.
594 mi = 955.53 kms