There are
1,345 mi
from Sioux Falls, SD to Chapel Hill, NC
That's the driving distance. It would take 1 day 1 hour to go from Sioux Falls, South Dakota to Chapel Hill, North Carolina.
The flight distance (direct flight from Sioux Falls, SD to Chapel Hill, NC) is 1,072.65 mi.
1,345 mi = 2,164.85 kms