There are
1,362 mi
from Sioux Falls, SD to Cayce, SC
That's the driving distance. It would take 1 day 1 hour to go from Sioux Falls, South Dakota to Cayce, South Carolina.
The flight distance (direct flight from Sioux Falls, SD to Cayce, SC) is 1,068.07 mi.
1,362 mi = 2,192.16 kms