There are
716 mi
from Sioux Falls, SD to Cape Girardeau, MO
That's the driving distance. It would take 13 hours 8 mins to go from Sioux Falls, South Dakota to Cape Girardeau, Missouri.
The flight distance (direct flight from Sioux Falls, SD to Cape Girardeau, MO) is 572.97 mi.
716 mi = 1,151.77 kms