There are
619 mi
from Sioux Falls, SD to Cahokia, IL
That's the driving distance. It would take 11 hours 22 mins to go from Sioux Falls, South Dakota to Cahokia, Illinois.
The flight distance (direct flight from Sioux Falls, SD to Cahokia, IL) is 482.80 mi.
619 mi = 996.95 kms