There are
859 mi
from Sioux Falls, SD to Brownsville, TN
That's the driving distance. It would take 15 hours 52 mins to go from Sioux Falls, South Dakota to Brownsville, Tennessee.
The flight distance (direct flight from Sioux Falls, SD to Brownsville, TN) is 676.94 mi.
859 mi = 1,381.99 kms