There are
886 mi
from Sioux Falls, SD to Amherst, OH
That's the driving distance. It would take 16 hours 16 mins to go from Sioux Falls, South Dakota to Amherst, Ohio.
The flight distance (direct flight from Sioux Falls, SD to Amherst, OH) is 751.63 mi.
886 mi = 1,426.44 kms