There are
833 mi
from Sioux City, IA to Tupelo, MS
That's the driving distance. It would take 16 hours 7 mins to go from Sioux City, Iowa to Tupelo, Mississippi.
The flight distance (direct flight from Sioux City, IA to Tupelo, MS) is 705.10 mi.
833 mi = 1,340.08 kms