There are
1,016 mi
from Sioux City, IA to Opelousas, LA
That's the driving distance. It would take 18 hours 45 mins to go from Sioux City, Iowa to Opelousas, Louisiana.
The flight distance (direct flight from Sioux City, IA to Opelousas, LA) is 860.56 mi.
1,016 mi = 1.61 kms