There are
779 mi
from Sioux City, IA to Middletown, OH
That's the driving distance. It would take 14 hours 39 mins to go from Sioux City, Iowa to Middletown, Ohio.
The flight distance (direct flight from Sioux City, IA to Middletown, OH) is 658.20 mi.
779 mi = 1,253.34 kms