There are
387 mi
from Sioux City, IA to Middleton, WI
That's the driving distance. It would take 7 hours 48 mins to go from Sioux City, Iowa to Middleton, Wisconsin.
The flight distance (direct flight from Sioux City, IA to Middleton, WI) is 351.93 mi.
387 mi = 622.77 kms