There are
768 mi
from Sioux City, IA to Mesquite, TX
That's the driving distance. It would take 13 hours 41 mins to go from Sioux City, Iowa to Mesquite, Texas.
The flight distance (direct flight from Sioux City, IA to Mesquite, TX) is 672.59 mi.
768 mi = 1,235.73 kms