There are
721 mi
from Sioux City, IA to Mayfield, KY
That's the driving distance. It would take 13 hours 28 mins to go from Sioux City, Iowa to Mayfield, Kentucky.
The flight distance (direct flight from Sioux City, IA to Mayfield, KY) is 573.12 mi.
721 mi = 1,160.96 kms