There are
532 mi
from Sioux City, IA to Manitowoc, WI
That's the driving distance. It would take 10 hours 32 mins to go from Sioux City, Iowa to Manitowoc, Wisconsin.
The flight distance (direct flight from Sioux City, IA to Manitowoc, WI) is 452.91 mi.
532 mi = 855.53 kms