There are
1,645 mi
from Sioux City, IA to La Mesa, CA
That's the driving distance. It would take 1 day 5 hours to go from Sioux City, Iowa to La Mesa, California.
The flight distance (direct flight from Sioux City, IA to La Mesa, CA) is 1,308.35 mi.
1,645 mi = 2,647.19 kms