There are
334 mi
from Sioux City, IA to La Crosse, WI
That's the driving distance. It would take 6 hours 19 mins to go from Sioux City, Iowa to La Crosse, Wisconsin.
The flight distance (direct flight from Sioux City, IA to La Crosse, WI) is 275.18 mi.
334 mi = 537.12 kms