There are
644 mi
from Sioux City, IA to Herrin, IL
That's the driving distance. It would take 12 hours 1 min to go from Sioux City, Iowa to Herrin, Illinois.
The flight distance (direct flight from Sioux City, IA to Herrin, IL) is 506.52 mi.
644 mi = 1,036.43 kms