There are
1,179 mi
from Sioux City, IA to Greenville, SC
That's the driving distance. It would take 22 hours 7 mins to go from Sioux City, Iowa to Greenville, South Carolina.
The flight distance (direct flight from Sioux City, IA to Greenville, SC) is 919.99 mi.
1,179 mi = 1.61 kms