There are
456 mi
from Sioux City, IA to Grayslake, IL
That's the driving distance. It would take 9 hours 37 mins to go from Sioux City, Iowa to Grayslake, Illinois.
The flight distance (direct flight from Sioux City, IA to Grayslake, IL) is 426.29 mi.
456 mi = 733.63 kms