There are
275 mi
from Sioux City, IA to Gladstone, MO
That's the driving distance. It would take 5 hours 4 mins to go from Sioux City, Iowa to Gladstone, Missouri.
The flight distance (direct flight from Sioux City, IA to Gladstone, MO) is 247.31 mi.
275 mi = 442.60 kms