There are
549 mi
from Sioux City, IA to Festus, MO
That's the driving distance. It would take 10 hours 15 mins to go from Sioux City, Iowa to Festus, Missouri.
The flight distance (direct flight from Sioux City, IA to Festus, MO) is 432.63 mi.
549 mi = 883.91 kms