There are
542 mi
from Sioux City, IA to Edwardsville, IL
That's the driving distance. It would take 10 hours 9 mins to go from Sioux City, Iowa to Edwardsville, Illinois.
The flight distance (direct flight from Sioux City, IA to Edwardsville, IL) is 423.06 mi.
542 mi = 871.59 kms