There are
461 mi
from Sioux City, IA to Des Plaines, IL
That's the driving distance. It would take 9 hours 21 mins to go from Sioux City, Iowa to Des Plaines, Illinois.
The flight distance (direct flight from Sioux City, IA to Des Plaines, IL) is 436.48 mi.
461 mi = 742.55 kms