There are
730 mi
from Sioux City, IA to Defiance, OH
That's the driving distance. It would take 13 hours 43 mins to go from Sioux City, Iowa to Defiance, Ohio.
The flight distance (direct flight from Sioux City, IA to Defiance, OH) is 624.61 mi.
730 mi = 1,175.27 kms