There are
842 mi
from Sioux City, IA to Clarksdale, MS
That's the driving distance. It would take 15 hours 27 mins to go from Sioux City, Iowa to Clarksdale, Mississippi.
The flight distance (direct flight from Sioux City, IA to Clarksdale, MS) is 654.30 mi.
842 mi = 1,354.77 kms