There are
533 mi
from Sioux City, IA to Cahokia, IL
That's the driving distance. It would take 9 hours 58 mins to go from Sioux City, Iowa to Cahokia, Illinois.
The flight distance (direct flight from Sioux City, IA to Cahokia, IL) is 424.11 mi.
533 mi = 858.57 kms