There are
501 mi
from Sioux City, IA to Appleton, WI
That's the driving distance. It would take 9 hours 51 mins to go from Sioux City, Iowa to Appleton, Wisconsin.
The flight distance (direct flight from Sioux City, IA to Appleton, WI) is 418.85 mi.
501 mi = 805.60 kms