There are
678 mi
from Simpsonville, SC to Thibodaux, LA
That's the driving distance. It would take 12 hours 42 mins to go from Simpsonville, South Carolina to Thibodaux, Louisiana.
The flight distance (direct flight from Simpsonville, SC to Thibodaux, LA) is 605.55 mi.
678 mi = 1,091.81 kms