There are
778 mi
from Simpsonville, SC to Patchogue, NY
That's the driving distance. It would take 15 hours 32 mins to go from Simpsonville, South Carolina to Patchogue, New York.
The flight distance (direct flight from Simpsonville, SC to Patchogue, NY) is 653.76 mi.
778 mi = 1,251.31 kms